논문 2026, iScience, Patient-derived organoids support radiotherapy respons…
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SUMMARY
Predicting individual responses to radiotherapy remains a major challenge in esophageal cancer. This study
evaluated an cancer organoid-based diagnosis and reactivity prediction (CODRP) approach to estimate
pathological response and recurrence risk after neoadjuvant chemoradiotherapy (NCRT) in esophageal
squamous cell carcinoma. Organoids were established from endoscopic biopsy specimens and irradiated
with doses of 2, 4, or 8 Gy. Growth inhibition-based area under the curve (GI-AUC) and cell growth rates
were quantified and integrated with the clinical cancer stage to generate the CODRP index. Compared
with single-parameter models, the CODRP showed improved apparent predictive performance for patholog
ical response prediction in this feasibility cohort (sensitivity, 87.5%; specificity, 100%). Recurrence-free sur
vival was significantly higher in the CODRP-classified radiation-sensitive group (71.43%) than in the radia
tion-resistant group (10%) (p = 0.0103). These findings support the feasibility of applying CODRP to
radiotherapy response and recurrence risk prediction in esophageal squamous cell carcinoma.
Predicting individual responses to radiotherapy remains a major challenge in esophageal cancer. This study
evaluated an cancer organoid-based diagnosis and reactivity prediction (CODRP) approach to estimate
pathological response and recurrence risk after neoadjuvant chemoradiotherapy (NCRT) in esophageal
squamous cell carcinoma. Organoids were established from endoscopic biopsy specimens and irradiated
with doses of 2, 4, or 8 Gy. Growth inhibition-based area under the curve (GI-AUC) and cell growth rates
were quantified and integrated with the clinical cancer stage to generate the CODRP index. Compared
with single-parameter models, the CODRP showed improved apparent predictive performance for patholog
ical response prediction in this feasibility cohort (sensitivity, 87.5%; specificity, 100%). Recurrence-free sur
vival was significantly higher in the CODRP-classified radiation-sensitive group (71.43%) than in the radia
tion-resistant group (10%) (p = 0.0103). These findings support the feasibility of applying CODRP to
radiotherapy response and recurrence risk prediction in esophageal squamous cell carcinoma.
2026, BiotechnologyJournal, Rocking-InducedRapidFormationofTumorSpheroidsfor Scalable3DTumor-ImmuneCocultureAssays